Part 1: Introduction to Psychopharmacology

Psychopharmacology Tips by Dr. Bob

Numerous tips and links compiled by Dr. Robert Hsuing, Professor of Psychopharmacology at the University of Chicago

http://www.dr-bob.org/tips/

On-Line Pharmacokinetic Simulations

Online computer simulations of dose optimization in mathematical models of pharmacokinetics. Also includes Excel files containing the models, and links to other resources related to pharmacokinetics.

http://www.cop.ufl.edu/safezone/pat/pha5127/simulatn.htm

Drug Metabolism

Comprehensive information on the Chemistry and Enzymology of Drug Metabolism

http://www.drugmetabolism.co.uk/Default.aspx

Merck Manual: Drug Dynamics

Merckís primer on drug dynamics. Includes sections on drug action and site selectivity.

http://www.merck.com/mmhe/sec02/ch012/ch012b.html

ChemCases: Drug Pathways and Chemical Concepts

Professor Sally Boudinot at Kennesaw State University has authored this instructional website on the biochemistry involved in drug metabolism. This curriculum development project is supported by the National Science Foundation.

http://www.chemcases.com/pheno/index.htm

Interactive Clinical Pharmacology

A site developed to increase understanding of important and sometimes difficult concepts and principles in Clinical Pharmacology. It uses Macromedia Flash to facilitate user interaction. An excellent resource for students in medicine, pharmacology, and psychopharmacology.

http://icp.org.nz/index.htm

Neuroscience and Behavior at MIT

Complete audio recordings of the undergraduate course Neuroscience and Behavior, offered by the department of Brain and Cognitive Sciences at the Massachusetts Institute of Technology and taught by Professor Gerald Schneider.

http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-01Fall-2003/CourseHome/index.htm

Neuroscience for Kids: Neurotransmitters

The ABCís of neurotransmitters.

http://faculty.washington.edu/chudler/chnt1.html


Part 2: Drugs That Depress Brain Function: Sedative-Hypnotic Drugs

Alcohol Medical Scholars Program

The mission of the Alcohol Medical Scholars Program (AMSP) is to promote optimal education in medical schools regarding the identification and care of people with alcohol use disorders and other substance-related problems. This site provides full PowerPoint presentations as well as outlines on topics related to the diagnosis and treatment of alcoholism, as well as numerous biological topics.

http://www.alcoholmedicalscholars.org/

Understanding the Pharmacology of Ethanol

A comprehensive background on the pharmacokinetics and dynamics of ethyl alcohol. Written by Dr. David Benjamin, Professor of Forensic Toxicology at Boston University School of Medicine.

http://www.doctorbenjamin.com/etoh/etoh.htm

DEA Briefs and Backgrounds: Depressants

The official word on barbiturates, benzodiazepines, GHB, and the like.

http://www.usdoj.gov/dea/concern/depressants.html

Drugs, Brain, and Behavior: Tranquilizers and CNS Depressants

An interactive Flash module describing the effects and mechanisms of commonly abused depressants. Written by Ian Winship at the University of Alberta.

http://www.psych.ualberta.ca/~ITL/flash/depressants_draft.swf

ChemCases: History of Barbiturates

The social and medical history of barbiturate use, this site also has links to an in-depth discussion of phenobarbitol. Written by Professor Sally Boudinot at Kennesaw State University.

http://www.chemcases.com/pheno/pheno01.htm

Barbiturates: History and Chemistry

An overview of the chemistry of various barbiturates, includes links to interactive molecular animations.

http://www.ch.ic.ac.uk/rzepa/mim/drugs/html/barbiturate_text.htm

How Benzodiazepines Work

An animation of the mechanism of action of benzodiazepines on GABA receptors.

http://www.pharmamotion.com.ar/animation-benzodiazepines-diazepam-lorazepam-alprazolam.html


Part 3: Drugs Used to Treat Psychological Disorders

Serotonin Syndrome: Recognition and Management

A comprehensive write-up from U.S. Pharmacist. Includes analysis of serotonin syndrome and numerous case studies.

http://www.uspharmacist.com/oldformat.asp?url=newlook/files/feat/acf2fa6.htm

Frequently Asked Questions About Nefazodone (Serzone)

A number of questions about the SSRI Nefazodone answered by Dr. Ivan Goldberg of the New York Psychopharmacological Institute.

http://www.dr-bob.org/tips/nefazodone.html

STEP-BD: Systematic Treatment Enhancement Program for Bipolar Disorder

The official site describing STEP-BD, the NIMH-funded collaborative study on the treatment of bipolar disorder mentioned in the textbook.

http://www.stepbd.org/

CrazyMeds: The Good, the Bad, & the Funny of Neurological Medications

A large database of writing about numerous drugs used to treat psychological disorders.† This site was put together not by doctors but by a group of patients all of whom have had experience with psychiatric medication, this site contains both official (and well-cited) information as well as accounts of personal experiences with taking the drugs. 

http://www.crazymeds.us/index.htm

The Child Psychopharmacology Parentís Page

A series of web pages created for parents who have questions about
the use of prescription medicines to treat problems and psychiatric disorders in children and adolescents. Maintained by the University of Wisconsin School of Education.

http://www.mentalhealthinkids.wisc.edu/pharm/

Children and Adults with AHDH

A non-profit organization providing education, advocacy, and support for individuals with ADHD.

http://www.chadd.org/

Medications Used to Treat Parkinson's Disease

Part of a large database of information on Parkinsonís Disease, this site reviews the various pharmacological treatments for Parkinsonís.

http://www.ehealthmd.com/library/parkinsons-disease/PD_medication.html


Part 4: Psychostimulants

Cocaine Pharmacology

An interesting perspective on the pharmacology of cocaine from the Museo de la Coca in La Paz, Bolivia.

http://www.cocamuseum.com/htm/pharmacology.htm

The Social Pharmacology of Smokeable Cocaine: Not All It's Cracked Up to Be

A chapter introducing the pharmacology of crack cocaine. It discusses the different pharmacodynamics of smoking versus inhaling cocaine, and argues that a degree of the harm caused by crack and cocaine stems more from the social circumstances of their use than from their specific pharmacology.

http://www.druglibrary.org/schaffer/cocaine/crack.htm

Drugs, Brain, and Behavior: Stimulants and Antidepressants

An interactive Flash module describing the effects and mechanisms of commonly abused stimulants. Written by Ian Winship at the University of Alberta.

http://www.psych.ualberta.ca/~ITL/flash/stimulants_draft.swf

The Naked Scientists: Why Do Plants Produce Caffeine?

An article discussing the evolutionarily adaptive benefits of caffeine production in plants.

http://www.thenakedscientists.com/HTML/articles/article/dalyacolumn2.htm/

Does Coffee Really Give You A Buzz?

An article reporting on a study from Bristol University on how the physiological effects of caffeine change as people become dependent.

http://www.express.co.uk/posts/view/4664/Does-coffee-really-give-you-a-buzz-

Drugs.com: Ritalin

Consumer information on Ritalin and related drugs.

http://www.drugs.com/ritalin.html

This Is Your Brain On Nicotine

A look at a recent study from the Brookhaven National Laboratory that documents the effects of nicotine on dopamine production.

http://whyfiles.org/024nicotine/brainscan.html


Part 5: Analgesic Drugs and Psychedelics

WebMD: Ibuprofen

Consumer information on ibubprofen.

http://www.webmd.com/drugs/mono-9368-IBUPROFEN+-+ORAL.aspx?drugid=5166&drugname=Ibuprofen

FDA Evaluation of COX-2 Selective Drugs and NSAIDs

Information and links concerning the use of COX-2 selective inhibitors (e.g. Vioxx) and non-selective non-steroidal anti-inflammatory drugs (NSAIDs).

http://www.fda.gov/cder/drug/infopage/cox2/

Opioids: Past, Present, and Future

This site makes the case that Opioid agonists are necessary for some members of the population suffering from chronic pain, and presents a large amount of information of the history, social science, and psychopharmacology of opioid agonists and antagonists.

http://opioids.com/index.html

Substances of Abuse and Addiction: Opiates

Information on opiates and opioid receptor action with accompanying animations. From the Department of Pharmacology at the University of Sunderland.

http://abdellab.sunderland.ac.uk/Lectures/addiction/opiates1.html

Endocannabinoid System Network

This site has a very large amount of information on the endogenous cannabinoid system.† This link goes to an animated video about the biology of endocannabinoids.

http://www.endocannabinoid.net/videoAnimation/EcsAnimation.aspx

Erowid

A member-supported organization providing access to non-judgmental information about psychoactive plants and chemicals and related issues. They regularly work with academic, medical, and experiential experts to develop and publish new resources, as well as to improve and increase access to already existing resources.

http://www.erowid.org/

Spiders on Drugs

Photos of spider webs spun under the influence of various drugs, including THC, Mescaline, and LSD.

http://cannabis.net/weblife.html

Psychedelic Medicine: Mind Bending, Health Giving

A 2005 article from New Scientist on potential therapeutic uses for psychedelic drugs.

http://www.newscientist.com/channel/health/mg18524881.400


Part 6: Special Topics in Psychopharmacology

The Psychopharmacology of Herbal Medicine

The Journal of Psychiatry and Neuroscience reviews Marcello Spinellaís book The Psychopharmacology of Herbal Medicine: Plant Drugs That Alter Mind, Brain and Behavior.

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=165795

St. Johnís Wort and Depression

Criticism of St. Johnís Wort as a treatment for depression. Written by retired psychiatrist Stephen Barrett, MD.

http://www.quackwatch.org/01QuackeryRelatedTopics/DSH/stjohn.html

Ginkgo Biloba

Factsheet on ginkgo biloba from the National Center for Alternative and Complementary Medicine and the NIH. Reviews the uses for and studies of ginkgo.

http://nccam.nih.gov/health/ginkgo/

Kava and Kava Drinking

An interesting description of practices involving Kava on the island of Samoa. Originally published in Anthropological Quarterly in 1932.
http://kavaroot.com/History/Deihl_AnthroQ.htm

Facts and Figures on Steroids

The official word on steroids from the Office of National Drug Control Policy.

http://www.whitehousedrugpolicy.gov/drugfact/steroids/index.html

Steroids

View a 5 minute clip of an educational film about steroids and steroid abuse.

http://ffh.films.com/id/11209/Steroids.htm

Association Against Steroid Abuse: Ask the Doctor

Database of information and frequently asked questions about the medical aspects of steroids. This organizationís mission is to educate and safeguard against the abuse of anabolic steroids by providing crucial information and statistics on the dangers and issues surrounding anabolic steroid use.

http://www.steroidabuse.com/ask-the-doctor.html